Terms and Conditions of Use

Introduction

Welcome to www.neuroprobe.com (the “Site”). Please read all the Terms and Conditions of Use and the Site Privacy Policy before using this site.

Neuro Probe Incorporated (referred to as “NP”, “we”, “us” or “our”, as applicable) provides you with access to the Site subject to the terms and conditions contained in this Terms of Use Agreement (the “Agreement”). Please read this Agreement carefully. By accessing or using this Site, you agree without restriction to be bound by this Agreement. If you do not agree to follow and be bound by this Agreement, you may not access, use or download materials from this Site.

Please note that if you are an existing customer or supplier of NP, these terms are not intended to replace or modify those contained in your customer or vendor agreement. In case of an inconsistency, the terms and conditions of your written agreement will prevail over those contained herein. All NP products and services may also be subject to separate terms and conditions which govern their use.

NP reserves the right to update or modify this Agreement at any time without prior notice. Your use of this Site following any such change constitutes your agreement to follow and be bound by this Agreement as revised. For this reason, we encourage you to review this Agreement each time you use this Site. This Agreement was last revised on November 15, 2005.

Account Registration

Some of the functions of this Site may require creation of an account with us. As part of the registration process, visitors will select a User Name and Password, along with registration information, which must be accurate and updated. You may not select or use a User Name of another person with the intent to impersonate that person or use a User Name in which another person has rights without such person’s authorization. Failure to comply with the above shall constitute a breach of this Agreement, which may result in immediate termination of your account. You agree to take reasonable measures to protect the security of your password.

You are responsible for all usage or activity on your account, including use of the account by any third party authorized by you to use your User Name and Password. You shall notify NP of any known or suspected unauthorized use(s) of your account, or any known or suspected breach of security, including loss, theft, or unauthorized disclosure of your password or any other relevant registration details provided.

Site Privacy Policy

Our Privacy Statement and Consent to Use of Data (the “Privacy Policy”) is available on this Site and by accessing the Site, you are agreeing to be legally bound by the Privacy Policy. The Privacy Policy in its entirety is hereby incorporated into this Agreement by reference. To read our Privacy Policy please click here.

The Availablity of the Site and International Users
The Site is administered by NP in the United States. This Site and its contents (the “Content”) are designed to comply with United States laws and regulations and are intended for use by United States residents only. Access to the Site and the Content may not be legal by certain persons or in certain countries outside of the United States. If you access this Site from outside the United States, you do so at your own risk and are responsible for compliance with the laws of your jurisdiction. Materials published on this Site may refer to products or services that are not available in your country. Furthermore, NP makes no representation that the materials on the Site are appropriate or available for use at other locations outside of the United States and access to them from countries where their contents are illegal is prohibited. You should not construe anything on the Site as a promotion or solicitation for any product or for the use of any product that is not authorized by the laws and regulations of the country in which you are located.

Public and Unsolicited Information

Children under the age of eighteen should not submit any Public Information or Unsolicited Information containing personally identifiable data.

This Site may provide opportunities to provide NP feedback regarding this Site and our products and other unsolicited submissions (collectively, “Unsolicited Information”). You may only provide Unsolicited Information which meets the requirements of these Terms and Conditions.

Subject to the conditions provided herein, we accept innovative ideas for new products and technologies to our company by individuals and organizations not employed by or affiliated with NP so long as such inventions are covered by existing patents or are those for which patents have been applied for by the submitter. If you wish to submit any such ideas please contact our Business Development Group at 301-417-0014.

NP and its employees do not accept or consider other unsolicited ideas, including ideas for new advertising campaigns, new promotions, new products or technologies, processes, materials, marketing plans or new product names. Please do not send any original creative artwork, samples, demos, or other works. The sole purpose of this policy is to avoid potential misunderstandings or disputes when NP’s products or marketing strategies might seem similar to ideas submitted to NP. So, except under the circumstances described above relating to patented ideas or those for which you have filed a patent application, please do not send your unsolicited ideas to NP or anyone at NP.

If, despite our request that you not send us your ideas and materials, you still send them, and in the event you post Public Information on our Site, all such Public Information and all such Unsolicited Information will be considered NON-CONFIDENTIAL and NON-PROPRIETARY and NP and its affiliates are free to use such information for any purpose and in any manner whatsoever.

This Site may present opportunities to post information to public areas of the Site, such as bulletin boards (collectively, “Public Areas”), or to send along comments and feedback (any such information provided, “Public Information”). Although NP may, from time to time, monitor or review the information posted to the Public Areas of the Site, NP is under no obligation to do so, and assumes no responsibility or liability arising from the Content of such Public Areas or the Site in general or for any error, defamation, libel, slander, omission, falsehood, obscenity, pornography, profanity, danger, or inaccuracy contained in the Site.

You are prohibited from posting or transmitting any unlawful, threatening, libelous, defamatory, obscene, inflammatory, pornographic, or profane material or any material that could constitute or encourage conduct that would be considered a criminal offense, give rise to civil liability, or otherwise violate the law. NP will fully cooperate with any law enforcement authorities or court order requesting or directing NP to disclose the identity of anyone posting any such material.

Copyright Notice and Limitation on Use

No use should be made of materials on this Site, except as expressly authorized by this Agreement. All Site Content, including the selection, arrangement and design of the Content is owned either by NP or its licensors and is protected by copyright and other intellectual property laws. You may not modify, copy, reproduce, republish, upload, post, transmit or distribute in any way any Content, in whole or in part, including any code and software. You may download Content from the Site for your own personal, non-commercial use only, provided the Content is not modified in any way you keep intact all copyright and other proprietary notices and you include the phrase, “Used with permission of Neuro Probe, Inc.” when you display or otherwise use the Content.

Procedures for Claimed Copyright Infringement

If you believe that your work has been copied in a way that constitutes copyright infringement, please provide our Web site Services Department (16008 Industrial Drive, Gaithersburg, MD 20877 USA, Email: info@neuroprobe.com) with the following information:

  • a description of the copyrighted work that you claim has been infringed;
  • a description of where the material that you claim is infringing is located on the Site;
  • your address, telephone number and email address;
  • a statement by you that you have a good faith belief that the disputed use is not authorized by the copyright owner, its agent, or the law;
  • a statement by you, made under penalty of perjury, that the above information in your notice is accurate and that you are the copyright owner or duly authorized to act on the copyright owner’s behalf;
  • an electronic or physical signature of the person authorized to act on behalf or the owner of the copyright interest.

Trademark Notice

All of the trademarks, service marks and logos displayed on this Site (the “Trademark(s)”) are registered and unregistered trademarks of NP, its affiliates, or third parties. Nothing contained in this Site should be construed as granting, by implication, estoppel, or otherwise, any license or right in and to the Trademarks without the express written permission of NP or the applicable third party. Except as expressly provided in this Agreement, any use of the Trademarks found on the Site is strictly prohibited. Please note that the names of the companies and products mentioned on this site may be trademarks of their respective owners.

Links to Other Websites

This Agreement applies only to this Site. This Site may frame or contain references or links to other NP Web sites (the “Other NP Sites”) as well as other Web sites that are not operated by NP (the “Third Party Sites”). These references and/or links to the Third Party Sites are provided for your reference and convenience only, and do not imply any review or endorsement of the material on these Third Party Sites or any association with their operators. NP does not control these Third Party Sites and is not responsible for their content. Your access and use of the Third Party Sites (and any Web sites to which they link) is solely at your own risk.

Please note that other NP Sites are governed by their specific Terms and Conditions and Privacy Policies. We recommend that you carefully read those documents upon your entry to those other NP Sites.

No Framing Allowed

Elements of this Site are protected by copyright, trade dress, trademark, unfair competition, and other laws and may not be copied or imitated in whole or in part by any means, including but not limited to, the use of framing, deep linking or mirrors. None of the Content for our Site may be retransmitted without the express written consent of NP. If you are interested in linking to our Site, Contact Us for more information.

Dealings with Advertisers

Your correspondence or business dealings with, or participation in promotions of, advertisers found on or through the Site, including payment and delivery of related goods or services, and any other terms, conditions, warranties or representations associated with such dealings are solely between you and such advertiser. You agree that we are not responsible nor shall we be liable for loss or damage of any sort incurred as a result of any such dealings or as the result of the presence of such advertiser on the Site.

Disclaimer of Warranties

THIS SITE CONTAINS INFORMATION CONCERNING NP THAT MAY BE USEFUL TO OUR CUSTOMERS AND EMPLOYEES AS WELL AS TO THE GENERAL PUBLIC. HOWEVER, NP MAKES NO REPRESENTATIONS OR WARRANTIES AS TO THE ACCURACY OF ANY INFORMATION CONTAINED HEREIN AND EXPRESSLY DISCLAIMS ANY OBLIGATION TO UPDATE SAID INFORMATION.

THE SITE AND THE CONTENT ARE PROVIDED ON AN “AS IS,” “AS AVAILABLE” BASIS, WITHOUT WARRANTIES OF ANY KIND. THERE MAY BE DELAYS, OMISSIONS OR INACCURACIES IN THE CONTENT AND THE SITE. NP AND ITS AFFILIATES DO NOT WARRANT THE ACCURACY, COMPLETENESS, TIMELINESS, NON-INFRINGEMENT, TITLE, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE OF THE CONTENT OR THE SITE ITSELF, AND WE HEREBY DISCLAIM ANY SUCH EXPRESS OR IMPLIED WARRANTIES. NP DOES NOT REPRESENT OR WARRANT THAT THE CONTENT OF THIS SITE IS FREE OF VIRUSES, WORMS OR OTHER CODE THAT MAY MANIFEST CONTAMINATING OR DESTRUCTIVE PROPERTIES. BECAUSE SOME JURISDICTIONS DO NOT PERMIT THE EXCLUSION OF CERTAIN WARRANTIES, THESE EXCLUSIONS MAY NOT APPLY TO YOU.

Limitation of Liability

YOUR USE OF THIS SITE IS AT YOUR SOLE RISK. UNDER NO CIRCUMSTANCES, SHALL NP, ITS AFFILIATES OR ANY OF THEIR RESPECTIVE DIRECTORS, OFFICERS, EMPLOYEES, OR AGENTS, BE LIABLE FOR ANY DIRECT OR INDIRECT LOSSES OR DAMAGES ARISING OUT OF OR IN CONNECTION WITH YOUR USE OF OR INABILITY TO USE THIS SITE OR YOUR RELIANCE ON ANY CONTENT. THIS LIMITATION OF LIABILITY APPLIES TO ALL LOSSES AND DAMAGES OF ANY KIND WHATSOEVER, WHETHER DIRECT OR INDIRECT, GENERAL, SPECIAL, INCIDENTAL, CONSEQUENTIAL, EXEMPLARY OR OTHERWISE, INCLUDING WITHOUT LIMITATION, LOSS OF DATA, REVENUE OR PROFITS. THIS LIMITATION OF LIABILITY APPLIES WHETHER THE ALLEGED LIABILITY IS BASED ON CONTRACT, NEGLIGENCE, TORT, STRICT LIABILITY OR ANY OTHER BASIS AND EVEN IF AN AUTHORIZED REPRESENTATIVE OF NP OR ITS AFFILIATES HAS BEEN ADVISED OF OR SHOULD HAVE KNOWN OF THE POSSIBILITY OF SUCH DAMAGES.

SOME STATES DO NOT ALLOW THE EXCLUSION OF DAMAGES OR LIMITATION OF LIABILITY SET FORTH ABOVE, SO THIS LIMITATION OF LIABILITY MAY NOT APPLY TO YOU. IF ANY PART OF THIS LIMITATION OF LIABILITY IS FOUND TO BE INVALID OR UNENFORCEABLE FOR ANY REASON, THEN THE AGGREGATE LIABILITY OF NP AND/OR ITS AFFILIATES UNDER SUCH CIRCUMSTANCES SHALL NOT EXCEED, TWENTY ($20.00) DOLLARS IN THE AGGREGATE. IF ANY REMEDY HEREUNDER IS DETERMINED TO HAVE FAILED OF ITS ESSENTIAL PURPOSE, ALL LIMITATIONS OF LIABILITY, DISCLAIMERS AND EXCLUSIONS OF WARRANTIES AND DAMAGES SET FORTH IN THIS AGREEMENT SHALL REMAIN IN EFFECT.

Indemnification

In the event that any legal action is taken resulting from (i) your use of the Content or Site, including your breach of the terms of this Agreement, or (ii) any Unsolicited Information provided by you, you agree to defend, indemnify, hold harmless and pay any reasonable legal and accounting fees without limitation incurred by NP, its affiliates, its and their directors, officers, employees, agents, investors or licensors. NP shall provide notice to you of any such claim, suit, or proceeding. NP shall have the right, at its option and expense, to participate in the defense and/or settlement of any claim or action, or to assume the exclusive defense and control of any matter otherwise subject to indemnification by you without relieving your indemnification obligations. In no event shall you settle any suit or claim imposing any liability or other obligations on NP without its prior written consent.

General

You are responsible for obtaining and maintaining all telephone, computer hardware and other equipment needed for access to and use of the Site and all charges related thereto. NP reserves the right to alter or delete material from this Site at any time. This Site is controlled and operated by NP from within the United States. Any claim relating to, and the use of, this Site are governed by the laws of the State of Maryland, United States of America. By using this Site, you consent to personal jurisdiction in the federal and state courts located in the State of Maryland, for any action arising out of or relating to this Site or your use of this Site. Such courts shall have exclusive jurisdiction over all such actions. The United Nations Convention on Contacts for the International Sale of Goods does not apply to this Agreement.

This Agreement constitutes the entire agreement between you and NP with respect to your access to and/or use of this Site. Any claims arising in connection with your use of the Site or any Content must be brought within sixty (60) days of the date of the event giving rise to such action occurred. All provisions of this Agreement pertaining to indemnification, disclaimer or warranties, limitation of liability and proprietary rights shall survive the termination of this Agreement for any reason. If any provision of this Agreement is invalid or unenforceable, the remaining provisions will continue in full force and effect, and the invalid or unenforceable provision will be deemed superseded by a valid enforceable provision that closely matches the intent of the original provision. The failure by us to exercise or enforce any right or provision under this Agreement shall not constitute a waiver of such right or provision. All rights not expressly granted herein are hereby reserved.

Microplate Specifications

Each disposable Neuro Probe ChemoTx® system instrument comes with a disposable Neuro Probe microplate with a well volume of either 30µL or 300µL. These microplates are suitable for use in most standard automated densitometric and fluorescence readers. To determine suitability for your reader, consult the specifications provided with the reader and use the dimensional data for Neuro Probe microplates in the table below. For luminescence or scintillation counters requiring a white microplate, or to use optical-bottom, opaque plates in a fluorescence reader, see funnel plate information below.

Neuro Probe MB-series 96-well chemotaxis chambers are reusable but can be used with various disposable microplates. We recommend only the Neuro Probe 30µL microplate and a few microplates made by other manufacturers. In order to form an acceptable seal, the microplate must be uniform in well height and well-rim shape. Based on our own tests and feedback from our customers, we seek to identify and stock microplates that meet our sealing standards. Currently we offer the microplates listed below. Other plates may fail to seal properly. Use of oversize plates may damage the chamber and void the warranty.

Reusable 96-well inserts can be used instead of disposable microplates with MB-series chemotaxis chambers. The reusable inserts are also suitable for use in automated readers, and relevant dimensional information is given below.

See Chemotaxis Accessories for stock numbers, prices, and additional information on microplates and inserts for MB-series chambers.

Dimensions for Disposable Microplates and Reusable Inserts

Stock # 10x-x 11x-x MPC MP30 IA-100 IB-50 IC-25
Well Size (µL) 30 300 400 30 100 50 25
Overall Dimensions Length (cm) 12.779 12.784 12.776 12.779 12.776 12.776 12.776
Width (cm) 8.560 8.557 8.547 8.560 8.585 8.585 8.585
Thickness (cm) 0.8026 1.529 1.44 0.8026 0.394 0.343 0.394
Top of plate to bottom of well(mm) 1.981 11.912 11.3 1.981 3.2 2.77 3.13
Bottom of skirt to bottom of well(mm) 6.045 3.378 3.1 6.045 0.74 0.66 0.81
Well Locations* (mm) x1 14.409 14.409 14.4 14.409 14.315 14.315 14.315
x2 113.403 113.403 113.4 113.403 113.33 113.33 113.33
y1 11.326 11.326 11.3 11.326 11.35 11.35 11.35
y2 74.323 74.323 74.3 74.323 74.36 74.36 74.36
Well diameter @bottom(mm) 4.03 5.00 6.1 4.03 6.35 4.77 3.18

*All plates are 96-well, with 12 columns and 8 rows. x1 = distance from left edge of plate to center of first column; x2 = distance from left edge of plate to center of 12th column; y1 = distance from top of plate to center of first row; y2 = distance from top of plate to center of 8th row.

 

Transferring Well Contents With the 96-Well Funnel Plate

If you are using a low volume, 30µL microplate in a ChemoTx or MB-series instrument, and you wish to use a different microplate in your automated reader or scintillation counter, you may use a 96-well funnel plate (Stock# FP1) to transfer the contents of the 30µL plate to another microplate. After your cell assay is incubated and processed according to the protocol for using automated readers, place the large openings of the funnel plate over the wells of the 30µL plate and position the second microplate over the funnel plate so that the small funnel openings are in the wells. Invert the assembly composed of the funnel plate and two microplates, then centrifuge it to move the cells into the second microplate.

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Behavior, reproduction, and immunity of crated pregnant gilts: Effects of high dietary fiber and rearing environment

The objective of this study was to examine effects of increased gut fill and diverse developing environments on pregnant gilts’ behavior and physiology. Gilts were cross-fostered at 1 d of age and transferred to either an indoor or outdoor production unit. Littermate gilts remained in their different environments during development and were moved into individual gestation crates in an indoor gestation unit. Of the 42 gilts, 19 were fed a control diet of fortified sorghum-soybean meal and 23 were fed the same diet with 25% beet pulp (high fiber). Control sows ate 2.0 kg/d and high-fiber sows ate 2.67 kg/d in a large pellet (thus resulting in approximately equal energy intake and differing total dietary intakes). Pregnant gilts had behavior and immune measures sampled at 30, 60, and 90 d of gestation. The day x diet interaction was significant (P = 0.01) for duration of standing: sows fed high-fiber diets stood less on d 30, but on d 60 and 90 they and the control sows stood for a similar duration. Sham chewing duration and frequency showed significant (P < 0.05) effects of gestation stage x diet x environment. Gilts reared outdoors and fed high fiber increased sham chewing over gestation, whereas all other treatment groups decreased this behavior over time. Outdoor-reared gilts had greater (P < 0.05) frequency and duration of drinking behavior than indoor-reared gilts. White blood cell numbers were higher (P < 0.05) for gilts fed high-fiber diets than for gilts fed the control diet. Immune (humoral and cellular systems) and reproductive measures (farrowing rate and litter size) and plasma cortisol concentrations were generally not influenced (P > 0.10) by diets and rearing environments, suggesting that in spite of significant changes in behavior and feed intake gilts’ immune systems were not suppressed or enhanced. Behavioral data alone suggested that indoor-reared gilts showed fewer behavioral adaptations to the crates than outdoor-reared gilts. However, immune measures did not indicate that any treatments resulted in physiological effects indicative of stress.

link to pdf at: http://www.journalofanimalscience.org/content/79/6/1466.long