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Effect of PDGF, IL-la, and BMP2/4 on Corneal Fibroblast Chemotaxis: Expression of the Platelet- Derived Growth Factor System in the Cornea

PURPOSE. The purpose of this study was to examine expression of platelet-derived growth factor (PDGF) and PDGF receptors in the human cornea and to study the effects of the PDGF isotypes on proliferation and chemotaxis of human corneal fibroblasts. The effects of interleukin (IL)-lai, bone morphogenic protein (BMP)2, and BMP4 on chemotaxis of human corneal fibroblasts were also studied.