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CD28 Signaling in Neutrophil Induces T-Cell Chemotactic Factor(s) Modulating T-Cell Response

ABSTRACT: We previously reported that human peripheral
blood neutrophils express CD28 and interact
with macrophage B7 to generate CD28 signaling through
PI-3 kinase. Here, we demonstrate that crosslinking of
CD28 on neutrophils results in the release of IFN-,
which restricts amastigote growth and modulates CD4
T cells cytokine secretion. CD28 crosslinking also induces
a T-cell chemotactic factor (TCF) that induces chemotactic
migration of CD4 T cells. Based on our previous and
the current set of data, we propose an operational model
explaining how neutrophils are involved in Leishmania
infection and how the reported effect of neutrophils on the
control of infection is mediated by alteration of T-cell
function. Human Immunology 64, 38–43 (2003). ©
American Society for Histocompatibility and Immunogenetics,
2003. Published by Elsevier Science Inc.…/Venuprasad-K-HumImmunol-2003.pdf